The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable (Nature Medicine)

Nature Medicine: The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable. “Recently, we described flaws in one randomized control trial of ivermectin, the results of which represented more than 10% of the overall effect in at least two major meta-analyses. We described several irregularities in the data that could not be consistent with them being experimentally derived4. That study has now been withdrawn by the preprint server on which it was hosted. We also raised concerns about unexpected stratification across baseline variables in another randomized controlled trial for ivermectin6, which were highly suggestive of randomization failure.”

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