The Guardian: AI firm DeepMind puts database of the building blocks of life online

The Guardian: AI firm DeepMind puts database of the building blocks of life online. “Last year the artificial intelligence group DeepMind cracked a mystery that has flummoxed scientists for decades: stripping bare the structure of proteins, the building blocks of life. Now, having amassed a database of nearly all human protein structures, the company is making the resource available online free for researchers to use.”

Engadget: Researchers retrofit microscopes to take 3D images of cells in real-time

Engadget: Researchers retrofit microscopes to take 3D images of cells in real-time. “There’s a limit to what you can learn about cells from 2D pictures, but creating 3D images is a time-intensive process. Now, scientists from UT Southwestern have developed a new ‘simple and cost-effective’ device capable of capturing multi-angle photos that can be retrofitted onto existing lab microscopes. The team say their solution — which involves inserting a unit of two rotating mirrors in front of a microscope’s camera — is 100 times faster than converting images from 2D to 3D.”

Phys .org: New AI-based tool can find rare cell populations in large single-cell datasets

Phys .org: New AI-based tool can find rare cell populations in large single-cell datasets. “Researchers at The University of Texas MD Anderson Cancer Center have developed a first-of-its-kind artificial intelligence (AI)-based tool that can accurately identify rare groups of biologically important cells from single-cell datasets, which often contain gene or protein expression data from thousands of cells. The research was published today in Nature Computational Science.”

ScienceDaily: New virtual reality software allows scientists to ‘walk’ inside cells

ScienceDaily: New virtual reality software allows scientists to ‘walk’ inside cells. “The software, called vLUME, was created by scientists at the University of Cambridge and 3D image analysis software company Lume VR Ltd. It allows super-resolution microscopy data to be visualised and analysed in virtual reality, and can be used to study everything from individual proteins to entire cells.”

UCLA: Researchers convert 2D images into 3D using deep learning

UCLA Newsroom: Researchers convert 2D images into 3D using deep learning. “A UCLA research team has devised a technique that extends the capabilities of fluorescence microscopy, which allows scientists to precisely label parts of living cells and tissue with dyes that glow under special lighting. The researchers use artificial intelligence to turn two-dimensional images into stacks of virtual three-dimensional slices showing activity inside organisms.”

BioSpace: New Tool Allows View of Cell Division in 3D Models

BioSpace: New Tool Allows View of Cell Division in 3D Models. “The Integrated Mitotic Stem Cell merges images of 15 separate cellular components, creating a 3-dimensional map of what a human cell looks like during different steps in cell division. The idea is that it can assist researchers in better understanding how the separate stages and different components of the cell work together—it’s also visually beautiful and entertaining, which makes it a valuable educational tool.”

UPI: Scientists use artificial intelligence to create cell database

UPI: Scientists use artificial intelligence to create cell database. “A new artificial intelligence could help sort normal cells from diseased cells, researchers report in a new study. The Human Cell Atlas is a deep learning algorithm method that uses single-cell RNA sequencing to distinguish activated and deactivated cells within humans at any point, according to a study published Wednesday in Nature Communications. The ability to pinpoint healthy cells from diseased cells at a given time within a person’s life cycle.”

Cancer. gov: Researchers create record-sized, integrated cellular cancer database

Cancer .gov: Researchers create record-sized, integrated cellular cancer database. “An international team of researchers have created a powerful new database that consolidates data on a record number of cancer drugs and cell lines. The freely available tool, called CellMinerCDB, can be used to explore connections between drugs and various features of cancer, such as genetic mutations, cell signatures, DNA methylation and more.”

DICE: Immune cell atlas goes live (EurekAlert)

EurekAlert: DICE: Immune cell atlas goes live . “Compare any two people’s DNA and you will find millions of points where their genetic codes differ. Now, scientists at La Jolla Institute for Immunology (LJI) are sharing a trove of data that will be critical for deciphering how this natural genetic variation shapes the immune system’s ability to protect our health.”

Allen Institute for Brain Science: Allen Institute for Brain Science Database Release Nearly Doubles Mouse Brain Cell Data

Allen Institute for Brain Science: Allen Institute for Brain Science Database Release Nearly Doubles Mouse Brain Cell Data. “The Allen Institute for Brain Science today announced the release of new data, tools to analyze those data and a new web-based 3D viewer to explore anatomy and connections in the mouse brain, the Allen Brain Explorer. Today’s data release almost doubles the number of mouse cells in the Allen Cell Types Database – raising the number included from just over 1,000 to slightly more than 1,900 cells – as well as adding new neuronal connectivity information to the Allen Mouse Brain Connectivity Atlas and adding more single-cell transcriptomics data from mouse, human and macaque brain cells.”

GeekWire: Biologists use artificial intelligence to flesh out 3-D views of a cell’s inner workings

GeekWire: Biologists use artificial intelligence to flesh out 3-D views of a cell’s inner workings. “What happens when you cross cell biology with artificial intelligence? At the Allen Institute for Cell Science, the answer isn’t super-brainy microbes, but new computer models that can turn simple black-and-white pictures of live human cells into color-coded, 3-D visualizations filled with detail. The online database, known as the Allen Integrated Cell, is now being made publicly available — and its creators say it could open up new windows into the workings of our cells.”

National Institutes of Health: NIH program to accelerate therapies for arthritis, lupus releases first datasets

National Institutes of Health: NIH program to accelerate therapies for arthritis, lupus releases first datasets .”Datasets characterizing individual cells in rheumatoid arthritis and systemic lupus erythematosus disease tissue from the Accelerating Medicines Partnership for Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Phase I study are now available to the research community. Scientists from across the biomedical research community can access the AMP RA/SLE datasets to explore important research questions about these autoimmune conditions.”

Human Cell Atlas: The plan to map every cell in your body (ABC News Australia)

ABC News (Australia): Human Cell Atlas: The plan to map every cell in your body. “Our bodies are made up of least 37 trillion cells, and scientists are teaming up around the world to map every single one of them. A new project called the Human Cell Atlas hopes to discover what each of these cells do. And the plan is to put the information in an online database that any scientist can use.”