Mint: Pfizer begins human trials of new pill to treat coronavirus

Mint: Pfizer begins human trials of new pill to treat coronavirus. “If it succeeds in trials, the pill could be prescribed early in an infection to block viral replication before patients get very sick. The drug binds to an enzyme called a protease to keep the virus from replicating. Protease-inhibiting medicines have been successful in treating other types of viruses, include HIV and Hepatitis C.”

Fierce Biotech: Clinical trial firms tap social media ‘influencers’ for virtual trial recruitment drive

Fierce Biotech: Clinical trial firms tap social media ‘influencers’ for virtual trial recruitment drive. “As the hype around so-called siteless trials continues unabated, two trial tech firms are joining forces to tap social media influencers to help push more patients into studies. The pair: decentralized clinical research company Thread and trial recruitment firm CureClick. They say their new pact will allow sponsors and contract research organizations to ‘access the power of patient activist-driven crowdsourcing to improve recruitment’ in virtual trials.”

Brief13: Major NIH-Funded Trial of Convalescent Plasma in Covid-19 Outpatients Stopped Early Due to Futility

Brief13: Major NIH-Funded Trial of Convalescent Plasma in Covid-19 Outpatients Stopped Early Due to Futility. “In another blow to convalescent plasma, the much-hyped proposed treatment for covid-19, the “Convalescent Plasma in Outpatient with COVID-19,” or ‘C3PO’ trial has stopped recruiting new patients and has been halted early, Brief19 has learned.”

National Library of Medicine: Progress Towards a Modernized ClinicalTrials. gov

National Library of Medicine: Progress Towards a Modernized ClinicalTrials.gov. “In 2019, NLM introduced a multi-year effort to modernize ClinicalTrials.gov, the world’s largest publicly accessible database of privately and publicly funded clinical trials. This effort was launched with a commitment to engage with and serve the millions of users who rely on this essential resource — with a focus on delivering an improved user experience on an updated platform that will accommodate growth and enhance efficiency.”

Analysis: More Black people need to be part of Covid-19 vaccine trials. Here’s why I participated (CNN)

CNN: Analysis: More Black people need to be part of Covid-19 vaccine trials. Here’s why I participated. “Dr. Kenneth Kim, the medical director and chief executive officer of Ark Clinical Research, says his office will administer shots to about 200 people in the trial and then follow up with them to learn how their bodies’ respond. Overall, the study involves about 40,000 people nationwide, according to Johnson & Johnson. But who signs up for these trials is key. That’s a large part of the reason why I wanted to volunteer for this Covid-19 vaccine research — more Black people and more people of color need to be part of these trials so more diverse populations can reap the benefits of this medical research. I believe in science and I hope my decision to join a trial and my transparency about the process will help more people trust today’s medicine.”

Covid: Trials to test combination of Oxford and Sputnik vaccines (BBC)

BBC: Covid: Trials to test combination of Oxford and Sputnik vaccines. “UK and Russian scientists are teaming up to trial a combination of the Oxford-AstraZeneca and Sputnik V vaccines to see if protection against Covid-19 can be improved. Mixing two similar vaccines could lead to a better immune response in people. The trials, to be held in Russia, will involve over-18s, although it’s not clear how many people will be involved.”

BBC: Oxford/AstraZeneca Covid vaccine ‘dose error’ explained

BBC: Oxford/AstraZeneca Covid vaccine ‘dose error’ explained. “On Thursday, multiple news outlets in the UK and US reported that there were questions over the data. They weren’t about safety, but rather how effective the jab is. The questions centre around efficacy levels. Three were reported from the trial – an overall efficacy of 70%, a lower one of 62% and a high of 90%. That’s because different doses of the vaccine were mistakenly used in the trial.”

Walter Isaacson: I participated in the Pfizer COVID trial at Ochsner. Here’s how it went. (NOLA)

NOLA: Walter Isaacson: I participated in the Pfizer COVID trial at Ochsner. Here’s how it went.. “One of the mixed blessings of living in New Orleans, in addition to being able to dance in the eye of a hurricane, is that our frequent health challenges make it easy to enroll in clinical trials In my case, it’s the trial of the COVID-19 vaccine from Pfizer, which just made big news with its good results.”

Covid: Brazil allows resumption of Chinese vaccine trial (BBC)

BBC: Covid: Brazil allows resumption of Chinese vaccine trial. “Brazil’s health regulator has announced that the trial of a Chinese coronavirus vaccine can resume. Anvisa suspended Brazil’s trial of the vaccine two days ago, citing a ‘severe adverse incident’ – reported to be the death of a volunteer. The head of the institute conducting the trial said the death had no connection to the vaccine.”

STAT News: Covid-19 vaccine from Pfizer and BioNTech is strongly effective, early data from large trial indicate

STAT News: Covid-19 vaccine from Pfizer and BioNTech is strongly effective, early data from large trial indicate. “The vaccine is the first to be tested in the United States to generate late-stage data. The companies said an early analysis of the results showed that individuals who received two injections of the vaccine three weeks apart experienced more than 90% fewer cases of symptomatic Covid-19 than those who received a placebo. For months, researchers have cautioned that a vaccine that might only be 60% or 70% effective.”

Cairo Scene: Egypt Now Accepting Volunteers For Covid-19 Vaccine Trial With New Website

Cairo Scene: Egypt Now Accepting Volunteers For Covid-19 Vaccine Trial With New Website. “News of a potential Coronavirus vaccine initially started circulating as little as two weeks into the pandemic, creating a lot of uncertainty throughout this already tumultuous period. However, it now seems now that more tangible news has popped up, bringing with it some potential for major advancements in the fight against the Coronavirus – the Ministry of Health are accepting volunteers to participate in the third phase of the clinical trials for the Coronavirus vaccine.”

Fierce Pharma: No need to panic about COVID-19 trial halts, FDA chief says. They show the system is working

Fierce Pharma: No need to panic about COVID-19 trial halts, FDA chief says. They show the system is working. “Headlines about COVID-19 vaccine and drug trial pauses may ring alarm bells for millions of people watching their progress, but FDA Commissioner Stephen Hahn, M.D., has another point of view. The breaks in the action actually show the development process is working as intended, Hahn told Bloomberg.”

KOAT: COVID-19 vaccine trials at Navajo Nation ‘overwhelmingly positive’

KOAT: COVID-19 vaccine trials at Navajo Nation ‘overwhelmingly positive’. “As COVID-19 vaccine trials around the world are put on hold because of safety concerns, the trials happening at the Navajo Nation are seeing great success. The nation became one of the first groups in the country to begin vaccine trials. Currently the medical team at the John Hopkins Center for American Indian Health, said that since the trials began in September at least 40 people have signed up to participate in the trials.”