Clinical Leader: New Website A Free Resource for Researchers, Patients On COVID-19 Trials

Clinical Leader: New Website A Free Resource for Researchers, Patients On COVID-19 Trials. “CoronaClinicalTrials.com features a robust search engine, powered by TrialScope technology, that enables site visitors to search for COVID-19 clinical trials by keyword or location. An advanced search function offers additional filters: distance, study status, study phase, as well as age and gender requirements for participants.”

Slate: Why We Can’t Just Let People Try Drugs That Might Treat COVID-19

Slate: Why We Can’t Just Let People Try Drugs That Might Treat COVID-19. “We have been here before. I worked with Dr. Anthony Fauci at the National Institutes of Health in the early days of AIDS, when many HIV-infected people demanded access to drugs for which there was little to no good data on their effects. This population faced a very high risk of rapid death, unlike the COVID-19 patients—yet some of them recognized that the best hope to control this horrible infection was the conduct of rigorous controlled studies that would actually show what worked and what didn’t. That approach ultimately led to the discovery of drugs that changed AIDS from a death sentence to a chronic disease but one that would not necessarily shorten life.”

Treatments for COVID-19: Drugs being tested against the coronavirus (LiveScience)

LiveScience: Treatments for COVID-19: Drugs being tested against the coronavirus. ” As of Friday (March 20), 86 clinical trials of COVID-19 treatments or vaccines that are either ongoing or recruiting patients. New ones are being added every day, as the case count in the U.S. (and globally) skyrockets. The drugs being tested range from repurposed flu treatments to failed ebola drugs, to malaria treatments that were first developed decades ago. Here, we take a look at several of the treatments that doctors hope will help fight COVID-19.”

Coronavirus (COVID-19) Update: FDA Issues Guidance for Conducting Clinical Trials (FDA)

FDA: Coronavirus (COVID-19) Update: FDA Issues Guidance for Conducting Clinical Trials. “The U.S. Food and Drug Administration today issued a guidance for industry, investigators and institutional review boards conducting clinical trials during the coronavirus (COVID-19) pandemic. The FDA recognizes that the COVID-19 pandemic may impact the conduct of clinical trials of medical products, including drugs, devices and biological products.”

Health IT Analytics: FDA Makes Real-World Data Available on Google Cloud Platform

Health IT Analytics: FDA Makes Real-World Data Available on Google Cloud Platform. “The FDA’s MyStudies platform, a tool that aims to collect real-world data to improve clinical trials and advance medical research, is now available on Google Cloud Platform. Launched in November 2018, the MyStudies open-source technology platform supports drug, biologic, and device organizations as they collect and report real-world data for regulatory submissions.”

Science: FDA and NIH let clinical trial sponsors keep results secret and break the law

Science: FDA and NIH let clinical trial sponsors keep results secret and break the law. “Science examined more than 4700 trials whose results should have been posted on the NIH website ClinicalTrials.gov under the 2017 rule. Reporting rates by most large pharmaceutical companies and some universities have improved sharply, but performance by many other trial sponsors—including, ironically, NIH itself—was lackluster. Those sponsors, typically either the institution conducting a trial or its funder, must deposit results and other data within 1 year of completing a trial. But of 184 sponsor organizations with at least five trials due as of 25 September 2019, 30 companies, universities, or medical centers never met a single deadline.”

Weill Cornell Medicine: Scientists Build the First Global Database and Roadmap for CAR Therapy Clinical Trials

Weill Cornell Medicine: Scientists Build the First Global Database and Roadmap for CAR Therapy Clinical Trials. “Weill Cornell Medicine scientists have built the first global database of clinical trials testing a rapidly expanding approach to cancer treatment that involves genetically modifying immune cells to recognize specific targets on a patient’s cancer cells and attack them. By analyzing the approach, called chimeric antigen receptor (CAR) therapies, the scientists designed a ‘therapeutic roadmap’ that identifies all current therapies as well as additional cancers that can be treated with them.”