News Medical: Social media use puts teens at risk of developing drug and alcohol issues

News Medical: Social media use puts teens at risk of developing drug and alcohol issues . “New research has found adolescents who are active on social media are being exposed to content that could put them at risk of developing drug and alcohol issues. The study, led by University of Queensland PhD student Brienna Rutherford from UQ’s National Centre for Youth Substance Use Research, examined how drug and alcohol use content was portrayed across social media.”

St. Louis Post-Dispatch: Missouri launches data dashboard to track rising drug overdose deaths

St. Louis Post-Dispatch: Missouri launches data dashboard to track rising drug overdose deaths. “In addition to an online COVID-19 data dashboard showing the seriousness of the pandemic, the state of Missouri has launched another public dashboard to track the increasing number of drug overdose deaths. Drug overdose has become the leading cause of death among Missouri adults age 18 to 44, state health officials say. More than 70% of the deaths involve opioids such as heroin and fentanyl.”

New York Times: Emergent Hid Evidence of Covid Vaccine Problems at Plant, Report Says

New York Times: Emergent Hid Evidence of Covid Vaccine Problems at Plant, Report Says. ” Emergent BioSolutions, a longtime government contractor hired to produce hundreds of millions of coronavirus vaccine doses, hid evidence of quality control problems from Food and Drug Administration inspectors in February 2021 — six weeks before it alerted federal officials that 15 million doses had been contaminated. The disclosure came in a report released Tuesday by House Democrats, who said that all told, nearly 400 million doses of coronavirus vaccine manufactured by Emergent had to be destroyed ‘due to poor quality control.’”

How Paxlovid came to be: From the germ of an idea to a vital tool against Covid (STAT News)

STAT News: How Paxlovid came to be: From the germ of an idea to a vital tool against Covid. “Charlotte Allerton, Pfizer’s head of medicine design, was making dinner — omelets — with her teenage children when she got a call from the one of company’s top development officers. He was calling with interim results from the study of an experimental antiviral for Covid-19. She pushed the food to one side and went upstairs. ‘It’s like any piece of news that you’re expecting,’ she said. ‘You can kind of tell just from the way the person speaks.’ She went directly to work. The drug in question would become Paxlovid, a medication that might finally get the pandemic under control — if only we can get it to patients.”

Anglia Ruskin University: Covid Hastens Demise Of Combined Contraceptive Pill

Anglia Ruskin University: Covid Hastens Demise Of Combined Contraceptive Pill. “GPs in England dramatically decreased their prescriptions of the combined contraceptive pill during the first Covid-19 lockdown and these rates have not recovered since, according to new research published in The European Journal of Contraception & Reproductive Health Care. The study, carried out by Anglia Ruskin University (ARU), analysed NHS prescribing data from general practices, because around 80% of women in the UK access the contraceptive pill through their GP.”

Another rare virus puzzle: They got sick, got treated, got covid again (Washington Post)

Washington Post: Another rare virus puzzle: They got sick, got treated, got covid again. “Infectious-disease experts agree that this phenomenon of the virus rebounding after some patients take the drug appears to be real but rare. Exactly how often it occurs, why it happens and what — if anything — to do about it remain matters of debate. What’s clear is that patients should be warned it is possible so they don’t panic — and so that they know to test again if they start feeling ill. More data is needed to understand what is going on. Paxlovid, made by the drug giant Pfizer, remains a useful drug, even though it has sparked a new mystery.”

WION: Japan’s antivirus pill shows ‘rapid clearance’ of COVID-19

WION: Japan’s antivirus pill shows ‘rapid clearance’ of COVID-19. “According to reports, an antiviral pill produced by a Japanese company showed ‘rapid clearance of the infectious COVID-19 virus’. The pharmaceutical company named Shionogi & Co Ltd said phase two results showed improvement in respiratory and feverish symptoms with the phase-3 trial set for worldwide testing with US government support.”

Bloomberg: Social-Media Scandal Costs Top Chinese Scientist $2 Billion

Bloomberg Quint: Social-Media Scandal Costs Top Chinese Scientist $2 Billion. ” Wu Yiling is one of China’s highest ranked scientists. With a fortune that neared $6 billion, he was also part of the world’s 500 richest people. That was until last week, when the son of another Chinese billionaire sparked debate online with a post doubting the efficacy of Wu’s drug used to treat Covid-19. The herbal remedy, Lianhua Qingwen, is one of three traditional treatments the central government has recommended and was sent to households in Shanghai and Hong Kong during the latest omicron wave.”

The GW Hatchet: Aspirin COVID-19 treatment reduces mortality among patients, SMHS study shows

The GW Hatchet: Aspirin COVID-19 treatment reduces mortality among patients, SMHS study shows. “School of Medicine and Health Sciences researchers found that aspirin can limit the mortality rate of patients with moderate COVID-19, according to a study published late last month. The study found that patients with moderate COVID-19 – which involves symptoms like fever and coughing combined with shortness of breath, sometimes requiring hospitalization – had a 1.6 percent lower mortality rate if they received aspirin during their first day of treatment.”

NBC News: Hundreds are still dying from Covid every day. Why is Paxlovid sitting on shelves?

NBC News: Hundreds are still dying from Covid every day. Why is Paxlovid sitting on shelves?. “More than 500 people are still dying of Covid-19 every day in the U.S., but an ample supply of a highly effectively antiviral drug is sitting on shelves, unused. The drug, Pfizer’s antiviral pill Paxlovid, was authorized for emergency use for high-risk people in December. Clinical trials found that a five-day course cut a patient’s risk of hospitalization and death by 89 percent.”

Stanford Medicine Scope: Bringing principles of ethics to AI and drug design

Stanford Medicine Scope: Bringing principles of ethics to AI and drug design. “Over the years, researchers have used AI to analyze troves of biological data, scouring for differences between diseased and healthy cells and using the information to identify potential treatments…. But with AI’s potential in drug development comes a slew of ethical pitfalls — including biases in computer algorithms and the philosophical question of using AI without human mediation. This is where the field of biomedical ethics — a branch of ethics focused on the philosophical, social and legal issues in the context of medicine and life sciences — comes in.”

UNC: A New Route for Remdesivir

UNC: A New Route for Remdesivir. “Scientists at the University of North Carolina at Chapel Hill are testing a new route for remdesivir, a pill form of the COVID-19 treatment that could make it accessible for early treatment. In laboratory tests, a modification of remdesivir was as effective as molnupiravir, another oral antiviral, at treating COVID-19 in mice. Further, the new drug compound can be adapted into a pill designed to halt coronaviruses before they multiply and cause severe disease.”

The Oregonian: Doctors finding hurdles to using pills to treat COVID-19

The Oregonian: Doctors finding hurdles to using pills to treat COVID-19. “The goal is to get patients started on either Pfizer’s Paxlovid tablets or Merck’s molnupiravir capsules within five days of symptoms appearing. That can prevent people with big health risks from growing sicker and filling up hospitals if another surge develops. But the tight deadline has highlighted several challenges. Some patients are delaying testing, thinking they just had a cold. Others have been unwilling or unable to try the new drugs.”