Coronavirus: US buys nearly all of Gilead’s Covid-19 drug remdesivir (BBC)

BBC: Coronavirus: US buys nearly all of Gilead’s Covid-19 drug remdesivir. “The US is buying nearly all the next three months’ projected production of Covid-19 treatment remdesivir from US manufacturer Gilead. The US health department announced on Tuesday it had agreed to buy 500,000 doses for use in American hospitals.”

NBC News: FDA pulls emergency use authorization of hydroxychloroquine for COVID-19

NBC News: FDA pulls emergency use authorization of hydroxychloroquine for COVID-19. “The Food and Drug Administration rescinded the emergency use authorization for hydroxychloroquine to treat hospitalized COVID-19 patients on Monday, saying the drug carries too many risks without any apparent benefit. The authorization was first issued in March, and applied to patients hospitalized with the illness and those in clinical trials. In April, the FDA warned doctors against prescribing the drug to COVID-19 patients outside of those settings. Monday’s action will not affect clinical trials, which are expected to continue.”

BBC: Dexamethasone is a first life-saving coronavirus drug

BBC: Dexamethasone is a first life-saving coronavirus drug. “A cheap and widely available drug called dexamethasone can help save the lives of patients who are seriously ill with coronavirus. UK experts say the low-dose steroid treatment is major breakthrough in the fight against the deadly virus. It cut the risk of death by a third for patients on ventilators. For those on oxygen, it cut deaths by a fifth.”

NIH: NIH-funded study to evaluate drugs prescribed to children with COVID-19

NIH: NIH-funded study to evaluate drugs prescribed to children with COVID-19. “Researchers funded by the National Institutes of Health have launched an effort to evaluate drugs prescribed to treat COVID-19 in infants, children and adolescents across the country. The study leverages an existing clinical trial that examines drugs that are prescribed off-label to children for a variety of medical conditions. Because many drugs have not been tested specifically for use in children, physicians will often prescribe drugs off-label to children because they lack an alternative, approved treatment.”

Politico: Florida ordered 1M doses of a Trump-touted drug. Hospitals didn’t want it

Politico: Florida ordered 1M doses of a Trump-touted drug. Hospitals didn’t want it. “Florida is sitting on more than 980,000 unused doses of hydroxychloroquine, a drug President Donald Trump touted as a ‘game changer’ in the fight against the coronavirus, after only a handful of hospitals in the state asked for access to the medicine.”

CNN: The US government’s supply of Covid-19 drug remdesivir runs out at the end of the month

CNN: The US government’s supply of Covid-19 drug remdesivir runs out at the end of the month. “The US government’s current supply of remdesivir, the only drug known to work against Covid-19, will run out at the end of the month, Dr. Robert Kadlec, a US Department of Health and Human Services official, told CNN. The government’s last shipment of the drug will go out the week of June 29. Gilead Sciences, the company that makes the drug, is ramping up to make more, but it’s unclear how much will be available this summer.”

The Daily Pennsylvanian: Penn Med professor leads research team on repurposing drugs for COVID-19 treatment

The Daily Pennsylvanian: Penn Med professor leads research team on repurposing drugs for COVID-19 treatment. “Penn researchers are studying how drugs that are typically prescribed for other diseases may also be used to treat coronavirus patients. Perelman School of Medicine Assistant Professor of Medicine David Fajgenbaum, who is leading the drug repurposing efforts, said doctors across the world have treated coronavirus patients with over 150 drugs so far. Fajgenbaum said he began studying the effectiveness of these drugs on March 13, with researchers from Penn’s Center for Cytokine Storm Treatment & Laboratory, the Castleman Disease Collaborative Network, which is his independent foundation, and the Medical School.”

BuzzFeed News: Internal FDA Documents Show How Little Evidence The Agency Had Before Allowing Malaria Drugs To Be Used To Treat COVID-19

BuzzFeed News: Internal FDA Documents Show How Little Evidence The Agency Had Before Allowing Malaria Drugs To Be Used To Treat COVID-19. “The Food and Drug Administration authorized two malaria drugs boosted by President Donald Trump to treat COVID-19 in March based on threadbare evidence, according to an agency review obtained by BuzzFeed News through a Freedom of Information Act lawsuit. The review also raised serious questions about shoddy practices at overseas factories that manufactured and donated the drugs for use in American hospitals, according to the documents.”

Washington Post: Antimalarial drug touted by President Trump is linked to increased risk of death in coronavirus patients, study says

Washington Post: Antimalarial drug touted by President Trump is linked to increased risk of death in coronavirus patients, study says. “A study of 96,000 hospitalized coronavirus patients on six continents found that those who received an antimalarial drug promoted by President Trump as a ‘game changer’ in the fight against the virus had a significantly higher risk of death compared with those who did not. People treated with hydroxychloroquine, or the closely related drug chloroquine, were also more likely to develop a type of irregular heart rhythm, or arrhythmia, that can lead to sudden cardiac death, it concluded.”

Trump Fans Gobble Up His Favorite, Unproven COVID Drug—Some Are Even Trying To Cook It Themselves (Daily Beast)

Daily Beast: Trump Fans Gobble Up His Favorite, Unproven COVID Drug—Some Are Even Trying To Cook It Themselves. “Donald Trump’s allies are seeking out hydroxychloroquine and even trying risky substitutes for the anti-malaria drug as it has become an emblem of the president’s unorthodox approach to fighting coronavirus. Trump has frequently touted hydroxychloroquine as a treatment for the disease, asking potential patients in April ‘what have you got to lose?’ But that enthusiasm took on an entirely new meaning Monday, when he claimed he’d been taking medication for ‘a couple of weeks.’ “

News Medical: New database of 14,000 known macrolactones could support drug discovery and research

News Medical: New database of 14,000 known macrolactones could support drug discovery and research. “Researchers from North Carolina State University and Collaborations Pharmaceuticals have created a free-to-use database of 14,000 known macrolactones – large molecules used in drug development – which contains information about the molecular characteristics, chemical diversity and biological activities of this structural class.”

Politico: Hydroxychloroquine shows no benefit against coronavirus in N.Y. study

Politico: Hydroxychloroquine shows no benefit against coronavirus in N.Y. study. “A decades-old malaria medicine touted by the president as a coronavirus treatment showed no benefit for patients hospitalized in New York. There was also no noticeable advantage for patients that took the drug paired with the antibiotic azithromycin, according to hotly anticipated research published Monday in the Journal of the American Medical Association.”

Bloomberg: Trump’s Virus Drug Whim Costs Millions, Even as the Mania Wanes

Bloomberg: Trump’s Virus Drug Whim Costs Millions, Even as the Mania Wanes. “President Donald Trump has stopped talking about the decades-old antimalarial drug he once touted as a ‘game changer’ for Covid-19, but it won’t be as simple for the rest of the health system to just move on. When Trump first began touting the drug in mid-March, a frenzy ensued as hospitals, patients and doctors raced to secure supplies. Many believed even if the drug didn’t turn out to be an effective coronavirus treatment, it might be able to ward off infection. But as quickly as pharmacies were drained of the pills, the tide has now turned against hydroxychloroquine and its chemical cousin, chloroquine.”