Sleep Review: Database Links Circadian Rhythms to Drug Metabolism in Human Tissues

Sleep Review: Database Links Circadian Rhythms to Drug Metabolism in Human Tissues. “Using new bioinformatics tools to analyze thousands of human tissue samples, researchers at Cincinnati Children’s Hospital Medical Center created a new database of daily rhythms in human gene activity—including many genes that regulate how drugs work.”

Pacific Standard: A New Website Shows Nearly Half Of E.U. Clinical Trial Data Isn’t Publicly Disclosed

Pacific Standard: A New Website Shows Nearly Half Of E.U. Clinical Trial Data Isn’t Publicly Disclosed. “Three researchers created a website earlier this year to name and shame pharmaceutical companies and universities in the United States that break a law that activists say is critical to patient safety. Now, the three have joined a few others to do the same for the European Union, creating a website that names 3,755 clinical trials—studies, done with human volunteers, of the safety and efficacy of new prescription drugs, vaccines, and medical devices—that have passed their deadlines for posting results publicly to the E.U. Clinical Trials Register.”

NoCamels: Scientists Harness AI, Deep Learning To Fast-Track Drug Discovery And Development

NoCamels: Scientists Harness AI, Deep Learning To Fast-Track Drug Discovery And Development. “The cost of developing a new pharmaceutical drug, from the research and development stage to market approval, runs at about $2.6 billion, according to a 2014 report published by the Tufts Center for the Study of Drug Development (CSDD) cited by the Scientific American. It also takes between 10 to 15 years. Israeli scientists say they have developed a revolutionary smart method to discover and develop new drugs, based on artificial intelligence and machine learning, that will dramatically shorten preparation time and reduce costs.”

Stanford: Database allows physicians to tailor prescriptions to complement an individual’s genome

Stanford: Database allows physicians to tailor prescriptions to complement an individual’s genome. “The database is a website that, through careful curation, collects information to help researchers, doctors and patients understand the intersection of genes and drugs, a field of study known as pharmacogenomics. Visitors to the site will find detailed information about molecular drug structures, metabolic pathways, and perhaps most valuably, specific genes that have the potential to influence how certain medications function in the body. Currently, the website…highlights about 5,500 genetic variants that affect the activity of 600 drugs.”

FDAAA Trials Tracker: leaderboard for pharma companies that break FDA clinical trial rules (Boing Boing)

Boing Boing: FDAAA Trials Tracker: leaderboard for pharma companies that break FDA clinical trial rules. “The US government currently requires all trials to be registered on ClinicalTrials.gov when they start — trials that aren’t reported in at their commencement are not eligible for consideration during FDA evaluation; and since ClinicalTrials.gov is public, it should be possible for the public and watchdogs to discover whether pharma companies are reporting in on all their trials. That’s where FDAAA Trials Tracker comes in: it downloads an XML dump from ClinicalTrials.gov, analyzes it, and tracks which trials are due or overdue, as well as ‘whether they have reported results in accor- dance with the law; give performance statistics for each individual trial sponsor; and calculate potential fines that could have been levied by the FDA against sponsors.'”

BusinessWire: OZMOSI Launches a Global Clinical Trials Database to Transform Drug Development Forecasting (PRESS RELEASE)

BusinessWire: OZMOSI Launches a Global Clinical Trials Database to Transform Drug Development Forecasting (PRESS RELEASE). “OZMOSI, an emerging leader in competitive intelligence and forecasting solutions for global pharmaceutical, biotech, and investment companies, announces the launch of a new global website which consolidates clinical trial data from all around the world into a single searchable database, GlobalClinicalTrialsData.com. Now anyone can use this free, real-time, global resource to search more than 280,000 trials covering over 3,700 disease areas to better understand and explore clinical trials in the pharmaceutical industry.”

C&E News: Online tool connects drug industry to U.K. academia

Chemical & Engineering News: Online tool connects drug industry to U.K. academia. “The Association of the British Pharmaceutical Industry (ABPI) has launched a public, online database that allows researchers from U.K. universities and other organizations to identify opportunities for collaborating with major drug companies.”